The recent revocation of the Ulipristal licence to indicate uterine fibroids has reminded the Pharmacovigilance community about the importance of Drug-induced liver injury, or DILI. Incidentally, DILI is one of the most typical reasons for product withdrawals.

Drug-induced liver injury (DILI) is uncommon but a potentially fatal cause of liver disease associated with medications and herbal and dietary supplements.

The two types include Intrinsic and idiosyncratic. DILI is also termed drug-induced hepatotoxicity.

Undoubtedly, one of the best (and free) online resources for DILI is LiverTox®. LiverTox® is an online e-book that is updated frequently. It provides up-to-date, unbiased and easily accessed information on the diagnosis, cause, frequency, clinical patterns and management of liver injury attributable to prescription and nonprescription medications and selected herbal and dietary supplements. The LiverTox site is meant as a resource for both physicians and patients as well as for clinical academicians and researchers who specialize in idiosyncratic drug-induced Liver Injury (DILI)

Information on specific medications or supplements can be found by entering their name in the “Search this book” box shown above or by browsing the list of agents by its first letter using the alphabetic list.

Ref: https://livertox.nih.gov/intro.html

LiverTox is maintained by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and is copyright free. However, they request that the use of LiverTox data in publications is given appropriate acknowledgement.

The next time you are looking for any resources on up-to-date information on the hepatotoxicity of medicinal products, make sure to have a look at this website.

Reference and Link to LiverTox: https://livertox.nih.gov/intro.html